
Siegel Lab
Infections with seemingly identical pathogens can lead to drastically different outcomes – as seen in the Corona pandemic. Such differences can be due to host specific factors or caused by cell-to-cell heterogeneity in pathogen populations.
The Siegel group aims to elucidate the mechanisms that control cell-to-cell heterogeneity in a population across different scales, i.e. how differences in genome sequence, chromatin organization and 3D genome architecture influence the expression of different surface antigens. A special focus of our work lies on understanding how ncRNA contribute to the organization of the 3D genome architecture and how RNA processing hotspots can serve as ‘post-transcriptional’ enhancers (Müller & Cosentino et al., Nature 2018, Faria & Luzak et al., Nature Microbiology 2021, Rabuffo et al., Nature Communications 2024).
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Lab News
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MicroC reveals T. brucei genome organisation at high resolution
Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes
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RNA processing and stability contribute to gene expression
We implemented SLAM-seq and TT-seq in African trypanosomes to study RNA maturation
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Tissue spaces are reservoirs of antigenic diversity for trypanosomes
Sleeping sickness: pathogens play hide-and-seek. Great collaboration with the Mugnier lab