Genome Assemblies

For the Trypanosoma brucei Lister 427 strain.

Version 12

An overview of the regions that have been modified.

© Siegel Lab

Full Name: Tb427v12

Changes since the last version
- 85 of the 103 remaining gaps in the genome were closed.
- 74 regions were identified to be missized. 63 of them have been corrected.
- Centromeres were annotated.
- Transcription start site annotations on chromosome 9 were corrected (they were shifted by ~15kb before).

Links
Download files (direct download)
Zenodo (details and versions)
Github (the used code)

Manuscript
Rabuffo C, Schmidt MR, Yadav P, Tong P, Carloni R, Barcons-Simon A, Cosentino RO, Krebs S, Matthews KR, Allshire RC, Siegel TN* (2024)
Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes.
Nature Communications 15: 10716 doi: 10.1038/s41467-024-55285-9

Version 11

Full Name: Tb427v11

Changes since the last version
- to be filled in

Links
Download files (direct download)
Zenodo (details and versions)
Github (the used code)

Version 10

Fully phased T. brucei Lister 427 genome.

This version is available on TriTrypDB.

Full Name: Tb427v10 / TriTrypDB-43_TbruceiLister427_2018

Changes since the last version
-
to be filled in

Links
Download files (direct download)
Zenodo (details and versions)

Manuscript
Cosentino RO*, Brink BG, Siegel TN* (2021)
Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay
NAR Genomics and Bioinformatics doi.org/10.1093/nargab/lqab082

Version 9

Long-read and Hi-C-based de novo assembly of the T. brucei Lister 427 genome

© Siegel Lab

Full Name: Tb427v9

Changes since the last version
- to be filled in

Links
Download files (direct download)
Zenodo (details and versions)

Manuscript
Müller LSM#, Cosentino RO#, Förstner KU, Guizetti J, Wedel C, Kaplan N, Janzen CJ, Arampatzi P, Vogel J, Steinbiss S, Otto TD, Saliba A-E, Sebra RP, Siegel TN* (2018)
Genome organization and DNA accessibility control antigenic variation in trypanosomes.
Nature
563: 121–125 doi.org/10.1038/s41586-018-0619-8