News overview
All news at a glance.
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We are part of the NUCLEATE Cluster of Excellence Network!Our lab is proud to be part of this growing collaborative research network aimed at studying the genome with “ever greater specificity and precision”.
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Image-activated cell sortingIt was a pleasure to contribute to this review highlighting the power of image activated cell sorting.
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Next generation genetic screens in kinetoplastidsThe state of the art and future applications of image-based and single-cell sequencing based genetic screens in kinetoplastids.
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Genomic Determinants of Antigen Expression Hierarchy in African TrypanosomesA highly sensitive single-cell RNA sequencing approach sheds light on the VSG-selection mechanisms in Trypanosoma brucei.
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Micro-C reveals T. brucei genome organisation at high resolutionInter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes
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RNA processing and stability contribute to gene expressionWe implemented SLAM-seq and TT-seq in African trypanosomes to study RNA maturation
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Tissue spaces are reservoirs of antigenic diversity for trypanosomesSleeping sickness: pathogens play hide-and-seek. Great collaboration with the Mugnier lab
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James is awarded with Marie Skłodowska-Curie Postdoctoral FellowshipsCongratulations James!
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Smoother: on-the-fly processing of interactome data using prefix sums
Check out our latest manuscript to learn how Hi-C and RADICL-seq data can be processed and visualized using an interactive interface
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Decoding the impact of nuclear organization on antigenic variation in parasites.Our review describes the importance of 3D genome architecture in the regulation of antigen expression.
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DFG funding to study antigenic variation in Uganda and KenyaApplication for PhD position opens soon.
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Our most complete and most accurate 427 Lister diploid genome assemblyThe peer-reviewed version is now online
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The CRC Chromatin Dynamics received funding for another 4 yearsWe still have one open PhD student position - apply now
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Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression
Our new manuscript has been published by Nature Microbiology.
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Can RNA-processing hotspots serve as post-transcriptional enhancers?Our new manuscript is now on bioRxiv
