Publications
members of the Meissner lab are listed in bold
# equal contribution
* corresponding authors
Meissner Lab Major Publications :
Watzlowik MT, Silberhorn E, Das S, Singhal R, Venugopal K, Holzinger S, Stokes B, Schadt E, Sollelis L, Bonnell VA, Gow M, Klingl A, Marti M, Llinás M, Meissner M, Längst G. Plasmodium blood stage development requires the chromatin remodeller Snf2L. Nature. 2025 Feb 19. DOI: 10.1038/s41586-025-08595-x
Li W, Grech J, Stortz JF, Gow M, Periz J, Meissner M, Jimenez-Ruiz E. A splitCas9 phenotypic screen in Toxoplasma gondii identifies proteins involved in host cell egress and invasion. Nat Microbiol. 2022 Jun;7(6):882-895. DOI: 10.1038/s41564-022-01114-y
Periz J, Del Rosario M, McStea A, Gras S, Loney C, Wang L, Martin-Fernandez ML, Meissner M. A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles. Nat Commun. 2019 Sep 13;10(1):4183. DOI:10.1038/s41467-019-12136-2
Periz J, Whitelaw J, Harding C, Gras S, Del Rosario Minina MI, Latorre-Barragan F, Lemgruber L, Reimer MA, Insall R, Heaslip A, Meissner M. Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. eLife. 2017 Mar 21;6:e24119. DOI: 10.7554/eLife.24119
Egarter S, Andenmatten N, Jackson AJ, Whitelaw JA, Pall G, Black JA, Ferguson DJ, Tardieux I, Mogilner A, Meissner M. The toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion. PLoS One. 2014 Mar 14;9(3):e91819. DOI: 10.1371/journal.pone.0091819
Andenmatten N, Egarter S, Jackson AJ, Jullien N, Herman JP, Meissner M. Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nat Methods. 2013 Feb;10(2):125-7. DOI: 10.1038/nmeth.2301
Herm-Götz A, Agop-Nersesian C, Münter S, Grimley JS, Wandless TJ, Frischknecht F, Meissner M. Rapid control of protein level in the apicomplexan Toxoplasma gondii. Nat Methods. 2007 Dec;4(12):1003-5. DOI: 10.1038/nmeth1134
Other publications:
Klinger CM, Jimenez-Ruiz E, Mourier T, Klingl A, Lemgruber L, Pain A, Dacks JB, Meissner M. (2024). Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans. Cell Reports, 43(2), 113740. DOI: 10.1016/j.celrep.2024.113740
Wagner M, Song Y, Jiménez-Ruiz E, Härtle S, Meissner M. (2023). The SUN-like protein TgSLP1 is essential for nuclear division in the apicomplexan parasite Toxoplasma gondii. Journal of Cell Science, 136(21), jcs260337. DOI: 10.1242/jcs.260337
Jimenéz-Ruiz E, Li W, Meissner M. (2024). Where is the EXIT? Phenotypic screens for new egress factors in apicomplexan parasites. Molecular Microbiology, 121(3), 359–367. DOI: 10.1111/mmi.15166
Singer M, Simon K, Forné I, Meissner M. (2023). A central CRMP complex essential for invasion in Toxoplasma gondii. PLoS Biology, 21(1), e3001937. DOI: 10.1371/journal.pbio.3001937
Spielmann T, Gras S, Sabitzki R, Meissner M. (2020). Endocytosis in Plasmodium and Toxoplasma parasites. Trends in Parasitology, 36(6), 520–532. DOI: 10.1016/j.pt.2020.03.010
Del Rosario M, Periz J, Pavlou G, Lyth O, Latorre-Barragan F, Das S, Pall GS, Stortz JF, Lemgruber L, Whitelaw JA, Baum J, Tardieux I, Meissner M. (2019). Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion. EMBO Reports, 20(12), e48896. DOI: 10.15252/embr.201948896
Gras S, Jimenez-Ruiz E, Klinger CM, Schneider K, Klingl A, Lemgruber L, Meissner M. (2019). An endocytic-secretory cycle participates in Toxoplasma gondii motility. PLoS Biology, 17(6), e3000060. DOI: 10.1371/journal.pbio.3000060
Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L, Meissner M. (2019). A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PLoS Pathogens, 15(4), e1007512.DOI: 10.1371/journal.ppat.1007512
Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung JM, Ward GE, Roberts CW, Meissner M. (2017). Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress but remain virulent in vivo. Wellcome Open Research, 2, 32. DOI: 10.12688/wellcomeopenres.11594.2
Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M. (2017). Surface attachment, promoted by the actomyosin system of Toxoplasma gondii, is important for efficient gliding motility and invasion. BMC Biology, 15(1), 1. DOI: 10.1186/s12915-016-0343-5
Harding CR, Egarter S, Gow M, Jiménez-Ruiz E, Ferguson DJ, Meissner M. (2016). Gliding-associated proteins play essential roles during the formation of the inner membrane complex of Toxoplasma gondii. PLoS Pathogens, 12(2), e1005403. DOI: 10.1371/journal.ppat.1005403
Jimenez-Ruiz E, Morlon-Guyot J, Daher W, Meissner M. (2016). Vacuolar protein sorting mechanisms in apicomplexan parasites. Molecular and Biochemical Parasitology, 209(1-2), 18–25. DOI: 10.1016/j.molbiopara.2016.01.007
Pieperhoff MS, Pall GS, Jiménez-Ruiz E, Das S, Melatti C, Gow M, Wong EH, Heng J, Müller S, Blackman MJ, Meissner M. (2015). Conditional U1 gene silencing in Toxoplasma gondii. PLoS ONE, 10(6), e0130356. DOI: 10.1371/journal.pone.0130356
Jiménez-Ruiz E, Wong EH, Pall GS, Meissner M. (2014). Advantages and disadvantages of conditional systems for characterization of essential genes in Toxoplasma gondii. Parasitology, 141(11), 1390–1398. DOI: 10.1017/S0031182014000559
Harding CR, Meissner M. (2014). The inner membrane complex through development of Toxoplasma gondii and Plasmodium. Cellular Microbiology, 16(5), 632–641. DOI: 10.1111/cmi.12285
Pieperhoff MS, Schmitt M, Ferguson DJ, Meissner M. (2013). The role of clathrin in post-Golgi trafficking in Toxoplasma gondii. PLoS ONE, 8(10), e77620. DOI: 10.1371/journal.pone.0077620
Jackson AJ, Clucas C, Mamczur NJ, Ferguson DJ, Meissner M. (2013). Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi complex. Traffic, 14(11), 1166–1181. DOI: 10.1111/tra.12102
Kremer K, Kamin D, Rittweger E, Wilkes J, Flammer H, Mahler S, Heng J, Tonkin CJ, Langsley G, Hell SW, Carruthers VB, Ferguson DJ, Meissner M. (2013). An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathogens, 9(3), e1003213. DOI: 10.1371/journal.ppat.1003213
Agop-Nersesian, C., Egarter, S., Langsley, G., Foth, B. J., Ferguson, D. J., & Meissner, M.
Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B.
PLoS Pathogens, 2010 Jul 29; 6(7):e1001029. PMID: 20686666.
DOI: 10.1371/journal.ppat.1001029
Breinich, M. S., Ferguson, D. J., Foth, B. J., van Dooren, G. G., Lebrun, M., Quon, D. V., Striepen, B., Bradley, P. J., Frischknecht, F., Carruthers, V. B., & Meissner, M.
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii.
Current Biology, 2009 Feb 24; 19(4):277-286. PMID: 19217293
DOI: 10.1016/j.cub.2009.01.039
Baum, J., Gilberger, T. W., Frischknecht, F., & Meissner, M.
Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma.
Trends in Parasitology, 2008 Dec; 24(12):557-563. PMID: 18835222 Review.
DOI: 10.1016/j.pt.2008.08.006
Kessler, H., Herm-Götz, A., Hegge, S., Rauch, M., Soldati-Favre, D., Frischknecht, F., & Meissner, M.
Microneme protein 8—A new essential invasion factor in Toxoplasma gondii.
Journal of Cell Science, 2008 Apr 1; 121(Pt 7):947-956. PMID: 18319299
DOI: 10.1242/jcs.022350
Agop-Nersesian, C., Pfahler, J., Lanzer, M., & Meissner, M.
Functional expression of ribozymes in Apicomplexa: towards exogenous control of gene expression by inducible RNA-cleavage.
International Journal of Parasitology, 2008 May; 38(6):673-681. PMID: 18062972
DOI: 10.1016/j.ijpara.2007.10.015