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Our Latest Research Published in Nature.
19 Feb 2025
Our team recently published in Nature and describe how a key protein helps malaria parasites survive and how blocking it could stop both the disease.
Malaria remains a global health threat, particularly in tropical regions. In our latest study, featured in Nature, we explored how the malaria parasite controls its own genes as it grows and spreads inside the human body.
Our team discovered that a specific protein, called PfSnf2L, plays a vital role in switching parasite genes on and off at exactly the right time. This protein is unlike anything seen in other organisms and is essential for the parasite’s survival and reproduction.
By targeting PfSnf2L with a newly developed compound, we were able to disrupt the parasite’s development — including the stage needed for mosquito transmission. This discovery not only deepens our understanding of malaria biology, but also opens the door to a new class of antimalarial drugs that could help stop the disease at its source.
More information here